Chapter 12 — Human Reproduction Exercise Solutions
Diagram questions (reproductive system, menstrual cycle graph) are very common. Practise neat labelled diagrams.
How to Use This Page
1. Start with the Key Concepts table to review every major term and its definition. 2. Work through MCQs to test recall of hormones, organs, and processes — these mirror 1-mark board questions. 3. Fill in the Blanks practises exact terminology — every blank is a word examiners look for. 4. True or False helps you spot common misconceptions about the menstrual cycle and gametogenesis. 5. Match the Following cements organ–function and hormone–phase pairs. 6. Answer Briefly gives you 2-mark answer templates — keep them within 3–5 sentences. 7. Answer in Detail provides structured 5-mark answer formats with sub-points and flow charts. 8. Common Mistakes to Avoid highlights exactly where students lose marks in this chapter. 9. Exam Checklist — use it as a final revision checklist before the exam.
Key Concepts (Quick Recap)
| Term | Definition |
|---|
| Spermatogenesis | Formation of sperms from spermatogonia in seminiferous tubules of testes |
| Oogenesis | Formation of ova from oogonia in the ovaries; begins before birth, completes at fertilisation |
| Seminiferous tubules | Coiled tubules in testes where spermatogenesis occurs; lined with Sertoli cells |
| Sertoli cells | Nourishing cells in seminiferous tubules that support developing sperm |
| Leydig cells | Interstitial cells in testes that produce testosterone |
| Ovulation | Release of a secondary oocyte from the Graafian follicle, triggered by LH surge (Day 14) |
| Menstrual cycle | 28-day cycle of changes in the ovaries and uterus, regulated by hormones |
| FSH | Follicle Stimulating Hormone — stimulates follicle growth in ovaries and spermatogenesis in testes |
| LH | Luteinising Hormone — surge triggers ovulation; stimulates corpus luteum to secrete progesterone |
| Oestrogen | Hormone from growing follicle; thickens endometrium; peak before ovulation |
| Progesterone | Hormone from corpus luteum; maintains endometrium for implantation |
| Corpus luteum | Yellow body formed from Graafian follicle after ovulation; secretes progesterone |
| Endometrium | Inner lining of uterus; thickens under oestrogen/progesterone; sheds during menstruation |
| Implantation | Embedding of blastocyst into the endometrium (Day 7 after fertilisation) |
| Placenta | Organ formed from maternal and foetal tissue; exchanges nutrients, gases, and wastes |
| Menarche | First menstrual period (puberty onset) |
| Menopause | Cessation of menstrual cycles (around age 45–55) |
Male Reproductive System — Key Organs
| Organ | Function |
|---|
| Testes | Produce sperms (spermatogenesis) + testosterone |
| Epididymis | Sperm maturation and temporary storage |
| Vas deferens | Conducts sperm toward urethra |
| Seminal vesicle | Secretes fructose-rich fluid (60% of semen volume) |
| Prostate gland | Secretes alkaline fluid (neutralises acidity) |
| Cowper's gland | Secretes pre-ejaculate (lubricates urethra) |
| Penis | Copulatory organ |
Spermatogenesis — Flow Chart
Spermatogonia (2n) → [Mitosis] → Primary spermatocytes (2n) → [Meiosis I] → Secondary spermatocytes (n) → [Meiosis II] → Spermatids (n) → [Spermiogenesis] → Spermatozoa (n)
Oogenesis — Flow Chart
Oogonium (2n) → Primary oocyte (2n) → [Meiosis I, arrested at birth] → [At puberty, each month] → Secondary oocyte (n) + First polar body → [After fertilisation] → Ovum (n) + Second polar body
Female Reproductive System — Key Organs
| Organ | Function |
|---|
| Ovaries | Produce ova + oestrogen + progesterone |
| Fallopian tubes (oviducts) | Transport ovum; site of fertilisation |
| Uterus | Site of implantation and foetal development |
| Cervix | Lower narrow part of uterus |
| Vagina | Birth canal; receives penis during copulation |
Menstrual Cycle Hormones
| Phase | Dominant Hormone | Event |
|---|
| Follicular | FSH, Oestrogen | Follicle growth, endometrium rebuilds |
| Ovulatory | LH surge | Ovulation (day 14) |
| Luteal | Progesterone | Endometrium maintained; corpus luteum active |
| Menstrual | All hormones fall | Endometrium shed |
I. Choose the Best Answer (MCQs)
1. The hormone that triggers ovulation is: (a) FSH   (b) Oestrogen   (c) LH   (d) Progesterone
Answer(c) LH
2. Spermatogenesis occurs in: (a) Epididymis   (b) Vas deferens   (c) Seminiferous tubules   (d) Prostate gland
Answer(c) Seminiferous tubules
3. The corpus luteum secretes: (a) FSH   (b) LH   (c) Oestrogen   (d) Progesterone
Answer(d) Progesterone
4. Meiosis II of the oocyte is completed: (a) Before birth   (b) At puberty   (c) At ovulation   (d) Only after fertilisation
Answer(d) Only after fertilisation
5. The site of fertilisation in humans is: (a) Uterus   (b) Ovary   (c) Fallopian tube (ampulla)   (d) Cervix
Answer(c) Fallopian tube (ampulla)
6. The inner lining of the uterus that thickens during the menstrual cycle is the: (a) Myometrium   (b) Endometrium   (c) Perimetrium   (d) Mesometrium
Answer(b) Endometrium
7. How many sperms are produced from one primary spermatocyte? (a) 1   (b) 2   (c) 4   (d) 8
Answer(c) 4
8. The hormone responsible for maintaining the endometrium during pregnancy is: (a) FSH   (b) LH   (c) Oestrogen   (d) Progesterone
Answer(d) Progesterone
9. Sertoli cells are found in: (a) Ovaries   (b) Seminiferous tubules   (c) Epididymis   (d) Vas deferens
Answer(b) Seminiferous tubules
10. Menarche refers to: (a) Cessation of menstruation   (b) First menstrual period   (c) Ovulation   (d) Implantation
Answer(b) First menstrual period
11. The placenta is formed from: (a) Only maternal tissue   (b) Only foetal tissue   (c) Both maternal and foetal tissue   (d) Uterine muscle
Answer(c) Both maternal and foetal tissue
12. Leydig cells produce: (a) Sperms   (b) Oestrogen   (c) Testosterone   (d) Progesterone
Answer(c) Testosterone
II. Fill in the Blanks
1. The process of sperm formation is called spermatogenesis. 2. The hormone that stimulates follicle growth in the ovaries is FSH (Follicle Stimulating Hormone). 3. Ovulation occurs around day 14 of a 28-day menstrual cycle. 4. The corpus luteum secretes progesterone after ovulation. 5. Fertilisation in humans occurs in the fallopian tube (ampulla region). 6. The inner lining of the uterus is called the endometrium. 7. The first menstrual period is called menarche. 8. Sertoli cells provide nourishment to developing sperms in the seminiferous tubules. 9. One primary spermatocyte produces 4 sperms after meiosis. 10. Implantation of the blastocyst occurs in the endometrium (uterus).
III. True or False (with corrections)
1.
AnswerFalse — The secondary oocyte completes meiosis before ovulation. → Correction: The secondary oocyte is arrested in Meiosis II at ovulation. Meiosis II is completed only after fertilisation by a sperm. If fertilisation does not occur, the secondary oocyte degenerates.
2.
AnswerTrue — LH surge triggers ovulation on approximately day 14 of the menstrual cycle.
3.
AnswerFalse — Progesterone is secreted by the Graafian follicle before ovulation. → Correction: Progesterone is secreted by the corpus luteum after ovulation. The Graafian follicle mainly secretes oestrogen before ovulation.
4.
AnswerTrue — Sertoli cells provide nutrition to developing sperms in the seminiferous tubules.
5.
AnswerFalse — One primary oocyte produces four functional ova. → Correction: One primary oocyte produces only one functional ovum and two or three polar bodies (which degenerate). This is because cytokinesis is unequal — most cytoplasm goes to the ovum.
6.
AnswerTrue — The placenta is formed from both maternal and foetal tissue and acts as the interface for nutrient and gas exchange.
7.
AnswerFalse — FSH and LH have the same function in the menstrual cycle. → Correction: FSH stimulates follicle growth in the ovaries; LH surge triggers ovulation. They have distinct roles.
8.
AnswerTrue — Menopause marks the cessation of menstrual cycles, typically occurring between ages 45–55.
IV. Match the Following
| Column A | Column B |
|---|
| 1. Testes | (f) Spermatogenesis and testosterone production |
| 2. Ovaries | (g) Oogenesis, oestrogen, and progesterone production |
| 3. FSH | (a) Stimulates follicle growth in ovaries |
| 4. LH | (e) Surge triggers ovulation |
| 5. Progesterone | (b) Maintains endometrium during pregnancy |
| 6. Corpus luteum | (d) Secretes progesterone after ovulation |
| 7. Sertoli cells | (c) Nourish developing sperms |
| 8. Epididymis | (h) Sperm maturation and storage |
V. Answer Briefly (2-mark)
1. Differentiate between spermatogenesis and oogenesis.
Answer
Spermatogenesis occurs in the seminiferous tubules of testes, starting at puberty, and produces millions of sperms continuously. Each primary spermatocyte produces 4 functional sperms. Oogenesis occurs in the ovaries, begins before birth (oogonia formed in foetal life), and produces one ovum per month at puberty. Each primary oocyte produces only 1 functional ovum and polar bodies.
2. What is the corpus luteum? What is its function?
Answer
The corpus luteum is a yellowish body formed from the remnants of the Graafian follicle after ovulation. It secretes progesterone, which maintains the thickened endometrium for potential implantation. If fertilisation does not occur, the corpus luteum degenerates, progesterone levels fall, and the endometrium is shed (menstruation).
3. What is implantation? Where does it occur?
Answer
Implantation is the embedding of the blastocyst (fertilised egg after several cell divisions) into the thickened endometrial lining of the uterus. It occurs approximately 6–7 days after fertilisation. After implantation, the embryo derives nutrition from the endometrium until the placenta forms.
4. State the functions of seminal vesicles and prostate gland.
Answer
The seminal vesicles secrete a fructose-rich alkaline fluid that provides energy for sperms and constitutes about 60% of semen volume. The prostate gland secretes a milky, alkaline fluid that neutralises the acidity of the vagina, helping sperms survive. Both fluids together with sperms form semen.
5. What is menopause?
Answer
Menopause is the permanent cessation of menstrual cycles, typically occurring between ages 45–55. It marks the end of a woman's reproductive life. It occurs because the ovaries no longer produce responsive follicles, leading to a decline in oestrogen and progesterone levels. Symptoms may include hot flashes, mood changes, and bone density loss.
VI. Answer in Detail (5-mark)
1. Describe the male reproductive system with the functions of each organ.
Answer
The male reproductive system consists of the following organs:
- Testes: A pair of oval organs located outside the abdominal cavity in the scrotum. The scrotum provides a temperature 2–3 degrees lower than body temperature, which is essential for spermatogenesis. Each testis contains about 250 compartments with seminiferous tubules where sperms are produced. Leydig cells (interstitial cells) between tubules secrete testosterone.
- Epididymis: A coiled tube on the posterior surface of each testis. Sperms produced in the seminiferous tubules are transported here for maturation and temporary storage. Sperms gain motility and the ability to fertilise during their passage through the epididymis (about 18–24 hours).
- Vas deferens: A muscular tube that carries sperms from the epididymis to the ejaculatory duct. It ascends through the inguinal canal into the abdominal cavity, loops over the ureter, and joins the duct of the seminal vesicle.
- Seminal vesicles: A pair of glands that secrete a thick, alkaline, fructose-rich fluid. This fluid provides energy (fructose) for sperm motility and constitutes about 60% of semen volume. The secretion also contains prostaglandins.
- Prostate gland: A single gland below the bladder that secretes a thin, milky, alkaline fluid. This neutralises the acidity of the vaginal secretions, protecting sperms and enhancing their viability.
- Cowper's glands (Bulbo-urethral glands): A pair of small glands below the prostate that secrete a clear, mucus-like pre-ejaculate fluid. This lubricates the urethra and neutralises any residual acidity from urine.
- Penis: The copulatory organ that delivers semen into the female reproductive tract during mating. It contains erectile tissue that engorges with blood during sexual arousal (erection). The urethra runs through the penis and serves as a common passage for both urine and semen.
2. Explain the menstrual cycle with hormonal regulation.
Answer
The menstrual cycle is a 28-day cycle of changes in the ovaries and uterus, regulated by hormones.
Phase 1 — Menstrual phase (Day 1–5):
- The endometrial lining, along with blood vessels and unfertilised ovum, is shed through the vagina as menstrual flow.
- Low levels of oestrogen and progesterone trigger this shedding.
Phase 2 — Follicular/Proliferative phase (Day 6–13):
- FSH (Follicle Stimulating Hormone) from the anterior pituitary stimulates the growth of a primary follicle into a Graafian follicle in the ovary.
- The growing follicle secretes oestrogen, which causes the endometrium to thicken and become vascularised (proliferation).
- Rising oestrogen levels also stimulate the cervix to produce thin, alkaline mucus favourable for sperm passage.
Phase 3 — Ovulatory phase (Day 14):
- A sharp surge in LH (Luteinising Hormone) triggers ovulation — the release of the secondary oocyte from the Graafian follicle.
- The oocyte is swept into the fallopian tube where fertilisation may occur.
Phase 4 — Luteal/Secretory phase (Day 15–28):
- After ovulation, the ruptured follicle transforms into the corpus luteum.
- The corpus luteum secretes progesterone (and some oestrogen), which maintains the thickened endometrium and makes it suitable for implantation.
- If fertilisation occurs: the corpus luteum persists, progesterone continues, and pregnancy is maintained.
- If fertilisation does NOT occur: the corpus luteum degenerates, progesterone and oestrogen levels fall, the endometrium breaks down, and menstruation begins — starting a new cycle.
Hormonal summary: FSH → follicle growth; Oestrogen → endometrium thickening; LH surge → ovulation; Progesterone → endometrium maintenance; Fall in progesterone → menstruation.
3. Describe spermatogenesis with a flow chart.
Answer
Spermatogenesis is the process of sperm formation from spermatogonia in the seminiferous tubules of the testes. It begins at puberty and continues throughout life.
Flow chart:
- Spermatogonia (2n) — diploid stem cells in the seminiferous tubules. They divide by mitosis to maintain their population.
- Primary spermatocytes (2n) — formed when spermatogonia grow and differentiate. Each undergoes Meiosis I.
- Secondary spermatocytes (n) — haploid cells produced after Meiosis I. Each undergoes Meiosis II.
- Spermatids (n) — haploid cells produced after Meiosis II. They are round, non-motile cells.
- Spermatozoa (n) — formed from spermatids by spermiogenesis (a process of morphological transformation). The spermatid develops a head (with acrosome containing enzymes), a middle piece (with mitochondria for energy), and a tail (flagellum for motility).
Key points:
- One primary spermatocyte produces 4 functional sperms.
- Sertoli cells (nurse cells) in the seminiferous tubules provide nutrition and support to developing sperms.
- The entire process takes about 64–72 days.
- Sperms are then transported to the epididymis for maturation and storage.
- Testosterone from Leydig cells is essential for spermatogenesis.
4. Describe the process of fertilisation and implantation.
Answer
Fertilisation:
- During intercourse, millions of sperms are deposited in the vagina. Only a few hundred reach the fallopian tube.
- The sperm undergoes capacitation (becomes capable of fertilising) in the female reproductive tract.
- Fertilisation occurs in the ampulla region of the fallopian tube when a sperm penetrates the secondary oocyte.
- The sperm releases enzymes from the acrosome (acrosomal reaction) that digest the outer layers (corona radiata and zona pellucida) of the oocyte.
- Upon penetration, the oocyte undergoes the cortical reaction, which blocks polyspermy (prevents additional sperms from entering).
- The sperm nucleus (n) fuses with the oocyte nucleus (n) to form the diploid zygote (2n). This fusion is called syngamy.
- Meiosis II of the oocyte is completed at this point, producing the ovum and the second polar body.
Cleavage and blastocyst formation:
- The zygote undergoes mitotic divisions (cleavage) as it moves through the fallopian tube toward the uterus.
- At the 16-cell stage, it is called a morula.
- The morula develops into a blastocyst — a hollow ball of cells with an inner cell mass (embryo) and an outer trophoblast layer.
Implantation:
- The blastocyst reaches the uterus about 4–5 days after fertilisation.
- Implantation occurs on about day 6–7 when the blastocyst embeds into the thickened endometrium.
- The trophoblast cells invade the endometrium and begin forming the placenta.
- After implantation, the embryo derives nutrition from the endometrium until the placenta is fully functional.
Placenta formation:
- The placenta is a disc-shaped organ formed from both maternal (endometrium) and foetal (trophoblast) tissue.
- It serves as the interface for exchange of nutrients, gases (O2 and CO2), and wastes between mother and foetus, without their blood mixing directly.
- The placenta also produces hormones (hCG, progesterone, oestrogen) to maintain pregnancy.
Worked Examples
Example 1 — Hormones of the menstrual cycle (model answer)
FSH → stimulates follicle growth (follicular phase)
LH → surge triggers OVULATION (~day 14)
Estrogen → repairs/thickens endometrium
Progesterone → maintains endometrium (luteal phase); fall → menstruation
Example 2 — Timing of meiosis in the oocyte (model answer)
The primary oocyte completes Meiosis I just before ovulation, releasing a secondary oocyte arrested in Meiosis II. Meiosis II is completed only if a sperm fertilises the oocyte — otherwise it degenerates.
Example 3 — Spermatogenesis ploidy
Spermatogonium (2n) → Primary spermatocyte (2n)
→ Meiosis I → Secondary spermatocyte (n)
→ Meiosis II → Spermatids (n) → Sperm (n)
One primary spermatocyte → 4 sperms.
Common Mistakes to Avoid
- Saying eggs complete meiosis before ovulation — secondary oocyte is in Meiosis II arrested state at ovulation. Meiosis II completes only after fertilisation.
- Confusing FSH (follicle stimulating) and LH (luteinising hormone) roles.
- Forgetting that corpus luteum forms from Graafian follicle after ovulation.
- ❌ "The secondary oocyte completes Meiosis II before ovulation" → ✅ "The secondary oocyte is arrested in Meiosis II at ovulation; Meiosis II completes only after fertilisation"
- ❌ "FSH triggers ovulation" → ✅ "LH surge triggers ovulation; FSH stimulates follicle growth"
- ❌ "Progesterone is secreted by the Graafian follicle" → ✅ "Progesterone is secreted by the corpus luteum (formed from the ruptured follicle after ovulation)"
- ❌ "One primary oocyte produces four ova" → ✅ "One primary oocyte produces only one functional ovum and two or three polar bodies (unequal cytokinesis)"
- ❌ "Spermatogenesis occurs in the epididymis" → ✅ "Spermatogenesis occurs in the seminiferous tubules; the epididymis is for maturation and storage"
- ❌ "Fertilisation occurs in the uterus" → ✅ "Fertilisation occurs in the fallopian tube (ampulla region); implantation occurs in the uterus"
- ❌ "Placenta is formed only from maternal tissue" → ✅ "Placenta is formed from both maternal (endometrium) and foetal (trophoblast) tissue"
Exam Checklist
- [ ] Can you label all organs of the male and female reproductive systems with their functions?
- [ ] Can you draw the spermatogenesis flow chart with ploidy at each stage?
- [ ] Can you draw the oogenesis flow chart and explain why only one ovum is produced?
- [ ] Can you explain the timing of meiosis in the oocyte (arrested at birth, completed at fertilisation)?
- [ ] Can you list the four phases of the menstrual cycle with days, hormones, and events?
- [ ] Can you match each hormone (FSH, LH, oestrogen, progesterone) to its specific role?
- [ ] Can you explain what the corpus luteum is and what happens if fertilisation does not occur?
- [ ] Can you describe fertilisation step by step — from sperm deposition to zygote formation?
- [ ] Can you explain implantation and placenta formation?
- [ ] Do you know the difference between Sertoli cells (nourish sperms) and Leydig cells (produce testosterone)?
- [ ] Can you state how many sperms are produced from one primary spermatocyte (4) vs one primary oocyte (1 ovum)?
- [ ] Can you define menarche and menopause?